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KMID : 0191120150300070991
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Journal of Korean Medical Science
2015 Volume.30 No. 7 p.991 ~ p.994
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Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea
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Yang Hae-Kyung
Ham Dong-Sik
Park Heon-Seok
Rhee Ma-Rie
You Young-Hye
Kim Min-Jung
Kim Ji-Won
Lee Seung-Hwan
Hong Tae-Ho
Choi Byung-Gil
Cho Jae-Hyoung
Yoon Kun-Ho
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Abstract
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Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet transplantation alone, using single-donor, marginal-dose islets in a Korean patient. A 59-yr-old patient with type 1 diabetes mellitus, who suffered from recurrent severe hypoglycemia, received 4,163 islet equivalents/kg from a single brain-death donor. Isolated islets were infused intraportally without any complications. The immunosuppressive regimen was based on the Edmonton protocol, but the maintenance dosage was reduced because of mucositis and leukopenia. Although insulin independence was not achieved, the patient showed stabilized blood glucose concentration, reduced insulin dosage and reversal of hypoglycemic unawareness, even with marginal dose of islets and reduced immunosuppressant. Islet transplantation may successfully improve endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus.
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KEYWORD
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Hypoglycemia, Islet Transplantation, Korea, Diabetes Mellitus Type 1
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